Dendritic cells and their implication in antitumor treatments

 

Main publications of the team in the field:

  •      Grégoire M. What's the place of immunotherapy in malignant mesothelioma treatment? Cell Adhesion and Migration,  4, (1), 153-161, 2010.
  •       Grégoire M. A near future for curative vaccine in mesotheliomaExpert Review of Respiratory Medicine  4(3), 311-314, 2010.
  •       Thomas Simon, J.-François Fonteneau, Marc Grégoire.  Dendritic cell preparation for immunotherapeutic interventions.  Immunotherapy 1: 2. 289-3020  2009.
  •       Remy, S., Blancou, P., Tesson, L., Tardif, V., Brion, R. ,Royer, P. J., Motterlini, R., Foresti, R., Painchaut, Pogu, S., Gregoire, M., Bach, J. M., Anegon, I., Chauveau, C. Carbon monoxide inhibits TLR-induced dendritic cell immunogenicity, J Immunol., 182(4):1867-1884, 2009
  •       Sapede C, Gauvrit A, Barbieux I, Padieu M, Cellerin L, Sagan C, Scherpereel A, Dabouis G, Grégoire M. berrant splicing and protease involvement in mesothelin release from epithelioid mesothelioma cells.Cancer Sci. Mar;99(3):590-4. 2008
  •       P. Larrieu, V. Renaud, Y. Godet, F. Jotereau and J.F. Fonteneau.P. A HLA-Cw*0701 restricted Melan-A/MART1 epitope presented by melanoma tumor cells to CD8+ tumor infiltrating lymphocytes. Cancer Immunol Immunother. 57(5):745-52. 2008.
  •       P. Larrieu, L.H. Ouisse, Y. Guilloux, F. Jotereau, and J.F. Fonteneau. A HLA-DQ5 restricted Melan-A/MART-1 epitope presented by melanoma tumor cells to CD4+ T lymphocytes. Cancer Immunol Immunother. 56(10):1565-75. 2007.
  •       Pierre-Joseph Royer, Gwenola Bougras, Frederic Ebstein, Lucie Leveque, Severine Tanguy-Royer, Thomas Simon, Nadine Juge-Morineau, Patrice Chevallier, Jean-Luc Harousseau, Marc Gregoire (2008) Efficient monocyte-derived dendritic cell generation in patients with acute myeloid leukemia after chemotherapy treatment: application to active immunotherapy. Exp Hematol 36: 3. 329-339 Mar 2008
  •       Clinical study : Multicentric study, a phase I/II immune cell therapy based on autologous dendritic cell injection loaded with autologous apoptotic blasts from acute myeloid leukemia in 2nd recovery.
  •       Royer Pierre-Joseph, Tanguy-Royer Severine, Ebstein Frederic, Sapede Carole, Simon Thomas, Barbieux Isabelle, Oger Romain, and Gregoire Marc. Culture medium and protein supplementation in the generation and maturation of dendritic cells. Scand. J. Imm. 63 (6), 401-409, 2006.

 Collaborators:

  1. ·         Dr. I. ANEGON, DR2, INSERM Unit 643, DC and tolerance (IDO, HO-1, Treg)
  2. ·         Development and clinical Transfer platform, Clinical Investigation Center in Biotherapies, (Ms D. COULAIS)

 DNA methylation and histone deacetylation inhibitors

 Main publications of the team in the field:

  • ®      Grigoriu, Chahine, Zerimech, Grégoire, Balduyck, Copin, Devos, Lassalle, Scherpereel (2009) Serum mesothelin has a higher diagnostic utility than hyaluronic acid in malignant mesothelioma. Clin Biochem 42 (10-11), 1046-1050, 2009.
  • ®      Bogdan-Dragos Grigoriu, Arnaud Scherpereel, Patrick Devos, Bachar Chahine, Marc Letourneux, Pierre Lebailly, Marc Grégoire, Henri Porte, Marie-Christine Copin, Philippe Lassalle (2007) Utility of osteopontin and serum mesothelin in malignant pleural mesothelioma diagnosis and prognosis assessment. Clin Cancer Res 13: 10. 2928-2935 May 2007
  • ®      Frédéric Ebstein, Carole Sapede, Pierre-Joseph Royer, Marie Marcq, Catherine Ligeza-Poisson, Isabelle Barbieux, Laurent Cellerin, Gérard Dabouis, Marc Grégoire. Cytotoxic T cell responses against mesothelioma by apoptotic cell-pulsed dendritic cells. Am J Respir Crit Care Med 169: 12. 1322-1330, 2004
  • ®      Delphine Massé, Frédéric Ebstein, Gwenola Bougras, Jean Harb, Khaled Meflah, Marc Grégoire (2004) Increased expression of inducible HSP70 in apoptotic cells is correlated with their efficacy for antitumor vaccine therapy. Int J Cancer 111: 4. 575-583, 2004

Collaborators :

  1. ·         SCHERPEREEL Arnaud, Service de Pneumologie et d’Oncologie Thoracique – Inserm U774, Lille
  2. ·         Ph. BERTRAND, CNRS de Synthesis et Reactivity of natural substitute, UMR 6514, Univ. Poitiers
  3. ·         Pierre-François CARTRON, Team 9 – U892, apoptotic process and resistance

 

Measles virus vaccine and cancer virotherapy

 

Main publications of the team in the field:

  • ®    Anne Gauvrit, Samantha Brandler, Carole Sapede-Peroz, Nicolas Boisgerault, Frédéric Tangy, Marc Gregoire. Measles virus induces oncolysis of mesothelioma cells and allows dendritic cells to cross-prime tumor-specific CD8 response. Cancer Res 68: 12. 4882-4892 Jun 2008.
  • ®    Nicolas Boisgerault, Frédéric Tangy,Marc Gregoire (2010). New perspectives in cancer virotherapy: bringing the immune system into play. Immunotherapy 2: 2. 185-99 Mar 2010.

Collaborators:

  1. ·        Dr. Frédéric TANGY (Laboratoire de Génomique Virale et Vaccination, Institut Pasteur):
  2. ·        Dr. François VALLETTE (Team 9 - U892): Apoptotic process and resistance

 

 

Dendritic cells iHDAC

Main publications of the team in the field:

  • ®    Mohty M, et al. pDCs and cancer: a new role for an enigmatic cell. Trends in Immunol. 25: 397-398, 2004.
  • ®    Mohty M, et al. Inflammatory cytokines and acute graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation. Blood. 2005 15; 106:4407-11.
  • ®    Mohty M, et al. Inflammatory cytokines and dendritic cells in acute graft-versus-host disease after allogeneic stem cell transplantation. Cytok & Growth Fact Rev. 19:53-63, 2008.
  • ®    Mohty M, et al. Association between BMI-1 expression, acute graft-versus-host disease, and outcome following allogeneic stem cell transplantation from HLA-identical siblings in chronic myeloid leukemia. Blood 2008; 112:2163-6.

 

Project feasibility: This research program relies on human material (peripheral blood and tissue samples collected retrospectively and prospectively) provided by the allo-SCT clinical program (>70 allo-SCT/year) directed by Pr M. Mohty at the CHU de Nantes.

Collaborators :

  1. ·        INSERM U892, Nantes (D. Valmori)
  2. ·        INSERM U645, Besançon (P. Saas and B. Gaugler)
  3. ·        Pathology Lab, Nantes, (JF Mosnier)